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Articles of Interest by

New Systematic Review and Meta-Analysis on Exercise Training

Summary: This systematic review and meta-analysis summarizes the effects of exercise training in adult, solid organ transplant recipients from 29 studies across heart, lung, liver, and kidney transplant. The results show that exercise training improved maximal exercise capacity, quadriceps muscle strength, health-related quality of life and diastolic blood pressure.

Position Statement on exercise for solid organ transplant candidates and recipients

Exercise for Solid Transplant Janaudis 2

To view an executive summary of the Position Statement, please click here

For a plain language summary, please click here

See a video summary of this article here

Perspectives of solid organ transplant recipients on the features in a digital heath tool

Summary: This qualitative study presents the perspectives of solid organ transplant (SOT) recipients on the features they would like to have in a digital heath tool (such as an app or web-based tool) to support their physical activity. 21 SOT recipients were interviewed for this study. The identified a reward system, affordability, integrating multiple aspects of health and self-management into a single tool and the ability to share information with peers and healthcare providers as key features. This information can assist in developing a tool that is centred around the needs of SOT recipients.

Exercise interventions in solid organ transplant candidates: A systematic review

Summary: This systematic review presents findings on acceptance, safety and effectiveness of exercise interventions in SOT (Solid Organ Transplant) candidates. Exercise capacity, health-related quality of life, safety and acceptance, were investigated in the twenty-three articles included in this study. Exercise training was shown to be acceptable and safe in selective SOT candidates. A lack of significant findings among randomized control trials was observed. The effects of exercise training on exercise capacity and quality of life are still to be determined.

Characteristics and Motivation of Solid Organ Transplant Recipients Attending the Canadian Transplant Games

Summary: This article presents the results of a survey of 157 transplant recipients who participated the Canadian Transplant Games, and their motivations to attending the Games. The main findings show that the most common reasons for participating in the games were to showcase good health after transplant, promote awareness of organ donation, competition in sports with other transplant athletes, and social reasons. Also, 65% of survey respondents reported that they would be interested in an exercise program to be more physically prepared for the competition

Disseminating Knowledge to Providers on Exercise Training After Solid Organ Transplantation

Janaudis-Ferreira T, Mathur S, Tansey CM, Blyndt-Hansen T, Hartell D. Prog Transplant. 2020 Apr 3:1526924820913506. doi: 10.1177/1526924820913506. [Epub ahead of print]

  • Summary: This article summarizes the steps taken to bring new scientific evidence about exercise in solid organ transplant candidates and recipients to healthcare professions at Canadian transplant centres. It also highlights the formation of CAN-RESTORE as a network focused on exercise and physical activity for solid organ transplant.
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​Physical rehabilitation for lung transplant candidates and recipients: An evidence-informed clinical approach.

Wickerson L, Rozenberg D, Janaudis-Ferreira T, Deliva R, Lo V, Beauchamp G, Helm D, Gottesman C, Mendes P, Vieira L, Herridge M, Singer LG, Mathur S. World J Transplant. 2016 Sep 24;6(3):517-31.

  • Summary: This review provides a practical approach to rehabilitation based on research and clinical practice at our transplant centre. It focuses on functional assessment and exercise prescription during an uncomplicated and complicated clinical course in the pre-transplant, early and late post-transplant periods.
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Physical activity in solid organ transplant recipients: Participation, predictors, barriers, and facilitators.

Gustaw T, Schoo E, Barbalinardo C, Rodrigues N, Zameni Y, Motta VN, Mathur S,3, Janaudis-Ferreira T. Clin Transplant. 2017 Apr;31(4)

  • Summary: This study describes the physical activity (PA) levels, predictors, barriers, and facilitators to PA in solid organ transplant (SOT) recipients using web-based questionnaire sent to members of the Canadian Transplant Association including the Physical Activity Scale for the Elderly (PASE), and questions regarding barriers and facilitators of PA.
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Meeting report: consensus recommendations for a research agenda in exercise in solid organ transplantation.

Mathur S, Janaudis-Ferreira T, Wickerson L, Singer LG, Patcai J, Rozenberg D, Blydt-Hansen T, Hartmann EL, Hawkowsky M, Helm D, High K, Howes N, Kamath BM, Lands L, Marzolini S and Sonnenday C. American Journal of Transplantation. 2014;14(10):2235-45.

  • Summary: This report provides a summary of a two-day meeting held in Toronto where a multi-disciplinary group of clinicians, researchers, administrators and patient representatives engaged in knowledge exchange and discussion of key research gaps in exercise training and rehabilitation in solid organ transplant.
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The World Transplant Games: An incentive to improve physical fitness and habitual activity in pediatric solid organ transplant recipients.

Deliva RD, Patterson C, So S, Pellow V, Miske S, McLister C, Manlhiot C, Pollock-BarZiv S, Drabble A and Dipchand AI. Pediatric Transplantation. 2014;18(8):889-95.

  • Summary: This study explored the impact of training for the World Transplant Games (WTG) on levels of health-related physical fitness and habitual activity in pediatric transplant recipients. It was determined that the WTG can provide a positive incentive for greater levels of physical activity and promote improvements in physical fitness levels.
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Exploring relationships among distress, psychological growth, motivation, and physical activity among transplant recipients.

Segatto BL, Sabiston CM, Harvey WJ and Bloom GA. Disability and Rehabilitation. 2013;35(24):2097-103.

  • Summary: This study examined the relationships among transplant-specific psychological growth and distress, motivational regulations and health-enhancing physical activity (HEPA) in transplant recipients. The findings demonstrated that a mix of stress and growth following transplantation was related to physical activity motivation and behaviour.
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Accelerometry-based physical activity and exercise capacity in pediatric kidney transplant patients.

Clark CG, Cantell M, Crawford S, Hamiwka LA. Pediatric Nephrology. 2012;27(4):659-65.

  • Summary: This goal of this study was to determine physical activity levels in pediatric transplant recipients. The data revealed that pediatric transplant recipients were not only inactive, but the activity they performed was overall of low intensity. Additionally, these transplant recipients showed compromised exercise capacity and physical fitness. These findings suggest a need to explore barriers to physical activity in transplant recipients.
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The exercise-during-hemodialysis program: report on a pilot study.

Ridley J, Hoey K and Ballagh-Howes N. Canadian Association of Nephrology Nurses and Technologists. 1999;9(3):20-6.

  • Summary: In exploring the effectiveness and feasibility of an exercise program in a hemodialysis centre, this pilot study found that exercise during a dialysis program is safe and has the potential to result in positive patient outcomes.
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Other Articles of Interest 

Exercise training in solid organ transplant recipients: a systematic review and meta-analysis.

Didsbury M, McGee RG, Tong A, Craig JC, Chapman JR, Chadban S and Wong G. Transplantation. 2013;95(5):679-87.

  • Summary: This article compiled the data from multiple studies to assess the health benefits and harms of supervised exercise training programs in transplant recipients. The findings revealed that exercise training is a promising intervention for improving the cardiovascular outcomes of this population. It also determined that most of the studies to date have been small, of short duration and focused on surrogate outcomes – this highlights a need for larger-scale studies.
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Seminars at the Canadian Transplant Centres

“Exercise in Solid Organ Transplantation: Current Evidence and Future Directions”

Drs. Tania Janaudis-Ferreira and Sunita Mathur visited the largest multi-organ transplant centres in Canada and presented about the best available evidence for exercise training and evaluation of physical function in solid organ transplant. This initiative was funded by a Dissemination Grant from the Canadian Institutes of Health Research (CIHR).

Presentations were conducted at centres in Montreal, Toronto, London, Edmonton, Vancouver and Halifax between April 2014 and April 2016.

Download a copy of the presentation.

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